Islet Patents (2)

US 5,834,308, "In Vitro Growth of Functional Islets of Langerhans," issued on November 10, 1998, expires 9 November 2015.

Abstract: The subject invention concerns new methods which make it possible, for the first time, to grow functional islet cells in in vitro cultures. The ability to grow these cells opens up important new avenues for research and therapy relating to diabetes.

Inventors:	Peck; Ammon B. (Gainesville, FL); Cornelius; Janet G. (Gainesville, FL)
Assignee:	University of Florida Research Foundation, Inc. (Gainesville, FL)
Filed:	April 28, 1994

US 6,001,647, "In Vitro Growth of Functional Islets of Langerhans and In Vivo Uses Thereof," issued on December 14, 1999, expires 27 April 2014.

Abstract: The subject invention concerns new methods which make it possible, for the first time, to grow functional islets in in vitro cultures. The subject invention also concerns the use of the in vitro grown islet-like structures for implantation into a mammal for in vivo therapy of diabetes. The subject invention further concerns a process using the in vitro grown islet implants for growing an organ in vivo that has the same functional, morphological and histological characteristics as those observed in normal pancreatic tissue. The ability to grow these cells in vitro and organs in vivo opens up important new avenues for research and therapy relating to diabetes.

Inventors:	Peck; Ammon B. (Gainesville, FL); Cornelius; Janet G. (Gainesville, FL)
Assignee:	Ixion Biotechnology, Inc. (Alachua, FL)
Filed:	October 25, 1995

Oxalate Patents (6)

U.S. Patent No. 5,604,111, "Method and Kit for Detection of Oxalate in a Fluid Sample," filed June 20, 1994, issued on 18 February 1997, expires 20 June 2014.

Abstract The subject invention concerns the novel use of formyl-CoA transferase enzyme together with oxalyl-CoA decarboxylase enzyme for the detection and measurement of oxalate in biological samples. The use of the enzyme system according to the subject invention results in the conversion of oxalate into carbon dioxide and formate. Because the production of formate is directly correlated to the concentration of oxalate present in a sample, the determination of the resulting formate concentration provides an accurate, sensitive and rapid means for detecting even low levels of oxalate.

Inventors:	Peck; Ammon B. (Gainesville, FL)
Assignee:	University of Florida Research Foundation (Gainesville, FL)
Filed:	June 20, 1994

U.S. Patent No. 5,837,833, "Materials and Methods for Detection of Oxalate" issued 17 November 1998, expires 20 June 2014.

Abstract The subject invention concerns the novel use of formyl-CoA transferase enzyme together with oxalyl-CoA decarboxylase enzyme for the detection and measurement of oxalate in biological samples. The use of the enzyme system according to the subject invention results in the conversion of oxalate into carbon dioxide and formate. Because the production of formate is directly correlated to the concentration of oxalate present in a sample, the determination of the resulting formate concentration provides an accurate, sensitive and rapid means for detecting even low levels of oxalate. The subject invention further concerns the cloning, sequencing and expression of the genes that encode the formyl- CoA transferase enzyme and the oxalyl-CoA decarboxylase enzyme of Oxalobacter formigenes. The subject invention also concerns a method for detecting the presence of Oxalobacter formigenes organisms in a sample, and the polynucleotide probes and primers used in the detection method.

Inventors:	Peck; Ammon B. (Gainesville, FL)
Assignee:	University of Florida Research Foundation, Inc. (Gainesville, FL)
Filed:	June 20, 1995

U.S. Patent No. 5,912,125, "Materials and Methods for Detecting Oxalobacter formigenes," issued on 15 June 1999, expires 20 June 2014.

Abstract: The subject invention concerns the novel use of formyl-CoA transferase enzyme together with oxalyl-CoA decarboxylase enzyme for the detection and measurement of oxalate in biological samples. The use of the enzyme system according to the subject invention results in the conversion of oxalate into carbon dioxide and formate. Because the production of formate is directly correlated to the concentration of oxalate present in a sample, the determination of the resulting formate concentration provides an accurate, sensitive and rapid means for detecting even low levels of oxalate. The subject invention further concerns the cloning, sequencing and expression of the genes that encode the formyl- CoA transferase enzyme and the oxalyl-CoA decarboxylase enzyme of Oxalobacter formigenes. The subject invention also concerns methods for detecting the presence of Oxalobacter formigenes organisms in a sample, and the polynucleotide probes and primers used in the detection method.

Inventors:	Peck; Ammon B. (Gainesville, FL); Sidhu; Harmeet (Gainesville, FL)
Assignee:	University of Florida (Gainesville, FL)
Filed:	September 27, 1996

U.S. Patent No. 6,090,628, "Materials and Methods for Detection of Oxalobacter," issued July 18, 2000, expires 20 June 2014.

Abstract: The subject invention concerns the novel use of formyl-CoA transferase enzyme together with oxalyl-CoA decarboxylase enzyme for the detection and measurement of oxalate in biological samples. The use of the enzyme system according to the subject invention results in the conversion of oxalate into carbon dioxide and formate. Because the production of formate is directly correlated to the concentration of oxalate present in a sample, the determination of the resulting formate concentration provides an accurate, sensitive and rapid means for detecting even low levels of oxalate. The subject invention further concerns the cloning, sequencing and expression of the genes that encode the formyl- CoA transferase enzyme and the oxalyl-CoA decarboxylase enzyme of Oxalobacter formigenes. The subject invention also concerns methods for detecting the presence of Oxalobacter formigenes organisms in a sample, and the polynucleotide probes and primers used in the detection method.

Inventors:	Peck; Ammon B. (Gainesville, FL); Sidhu; Harmeet (Gainesville, FL)
Assignee:	University of Florida (Gainesville, FL)
Filed	June 26, 1997

U.S. Patent No. 6,214,980, "Materials and Methods for Detection of Oxalobacter," issued on 10 April 2001, expires 20 June 2014.

Abstract: The subject invention concerns the novel use of formyl-CoA transferase enzyme together with oxalyl-CoA decarboxylase enzyme for the detection and measurement of oxalate in biological samples. The use of the enzyme system according to the subject invention results in the conversion of oxalate into carbon dioxide and formate. Because the production of formate is directly correlated to the concentration of oxalate present in a sample, the determination of the resulting formate concentration provides an accurate, sensitive and rapid means for detecting even low levels of oxalate. The subject invention further concerns the cloning, sequencing and expression of the genes that encode the formyl- CoA transferase enzyme and the oxalyl-CoA decarboxylase enzyme of Oxalobacter formigenes. The subject invention also concerns methods for detecting the presence of Oxalobacter formigenes organisms in a sample, and the polynucleotide probes and primers used in the detection method.

Inventors:	Peck; Ammon B. (Gainesville, FL); Sidhu; Harmeet (Gainesville, FL)
Assignee:	University of Florida (Gainesville, FL)
Filed:	September 23, 1997

U.S. No. 6,200,562, "Materials and Methods for Treating or Preventing Oxalate Related Disease," (claiming priority from provisional application U.S. 60/047,473, filed 23 May 1997), issued on March 13, 2001, expires May 22, 2018.

Abstract: This invention provides materials and procedures for the delivery of selected strains of bacteria and/or oxalate-degrading enzymes to the intestinal tracts of persons who are at increased risk for oxalate related disease because they have lost, or have inadequate concentrations of these bacteria. The administration of these bacteria and/or the relevant enzyme removes oxalate from the intestinal tract and thus reduces the amount of oxalate available for absorption and reduces the risk for oxalate related disease.

Inventors:	Allison; Milton J. (Ames, IA); Sidhu; Harmeet (Gainesville, FL)
Assignee:	Ixion Biotechnology, Inc. (Alachua, FL)
Filed:	May 22, 1998

Other Patents (1)

US 5,187,071, "Method for the Selective Control of Weeds, Pests, and Microbes," issued on 16 February 1993.

Abstract: A novel means for identifying selective control agents for weeds, pests, and microbes is provided. Novel compositions for the selective control of weeds, pests, and microbes are also provided. The critical elements in the novel method of the invention relate to the systematic and specific identification of points of diversity which exist between the target organism and the host or other non- target organisms. More specifically the process involves identifying a difference which exists between the metabolic pathway of a microbial or plant target organism and a non-target host specie and then preparing a control agent which perturbs the metabolic pathway of the target without significantly perturbing the metabolic pathway of the host.

Inventors:	Fischer; Randy S.; Jensen; Roy A.
Filed:	July 15, 1988